To explore the effect of palliative care on the psychological well-being and sleep quality of the primary caregivers of elderly patients with terminal cancer.
In this prospective study, a total of 102 elderly patients with terminal cancer and their primary caregivers were randomly divided into a study group and a control group of 51 patients each by a random number table. https://www.selleckchem.com/products/fluorofurimazine.html The control group was given routine end-of-life care and the study group was given palliative care. In this study, we compared adverse mood, sleep quality, psychological stress and satisfaction with care among primary caregivers before and after the intervention, as well as changes in patients' quality of life.
The Hamilton Anxiety Scale (HAMA), the Hamilton Depression Scale (HAMD), the Pittsburgh Sleep Quality Index (PSQI), and RSS scores of the primary caregiver were significantly lower in both groups after the intervention, and significantly lower in the study group (all P&lt;0.05). The Generic Quality of Life Inventory-74 (GQOLI-74) scores were significantly higher in both groups after the intervention, and significantly higher in the study group (all P&lt;0.05). In addition, the primary caregiver's satisfaction with care was significantly higher in the study group than that in the control group (96.08% vs. 82.35%, P&lt;0.05).
Palliative care for patients with terminal cancer can be effective in alleviating the poor psychological well-being of the primary caregivers, improving their sleep quality as well as improving nursing satisfaction and patients' quality of life.
Palliative care for patients with terminal cancer can be effective in alleviating the poor psychological well-being of the primary caregivers, improving their sleep quality as well as improving nursing satisfaction and patients' quality of life.To explore the changes in miR-221 and miR-222 before and after interventional therapy of coronary heart disease and their relationship with inflammatory factors and prognosis.
A total of 122 subjects with coronary heart disease who underwent interventional therapy in our hospital from January 2017 to January 2019 were chosen as the observation group, and 122 healthy people during the same period were chosen as the control group. We retrospectively analyzed the levels of serum miR-221, miR-222, C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6). Pearson correlation analysis was used to reveal the relationship between serum levels of miR-221, miR-222 and CRP, TNF-α and IL-6, N-terminal B-type brain natriuretic peptide precursor (NT-proBNP) and left ventricular ejection fraction (LVEF%) in the observation group. The levels of serum miR-221, miR-222, TNF-α, CRP and IL-6 before and after treatment were compared in the observation group. After a follow-up of 6 months, the obs (all P&lt;0.05). Both before and after treatment, the levels of miR-221 and miR-222 have certain clinical value in evaluating the prognosis (all AUC&gt;0.800).
The levels of miR-221 and miR-222 in patients with coronary heart disease significantly increased and they were closely correlated with the inflammatory factors, NT-proBNP and LVEF%. The levels of miR-221 and miR-222 before and after treatment have certain clinical value in evaluating the prognosis of patients.
The levels of miR-221 and miR-222 in patients with coronary heart disease significantly increased and they were closely correlated with the inflammatory factors, NT-proBNP and LVEF%. The levels of miR-221 and miR-222 before and after treatment have certain clinical value in evaluating the prognosis of patients.To study the effect of the three-dimensional nursing management mode on compliance with respiratory function exercises and on the nursing efficiency in post-thoracotomy, acute pulmonary embolism (PE) patients.
A cohort of 20 post-thoracotomy patients with acute PE were equally and randomly divided into two groups. The patients in the experimental group underwent the three-dimensional nursing management mode, and the patients in the control group underwent ordinary nursing. The compliance with respiratory function exercises during the hospital stay and within 3 months after discharge was observed, and the efficiency of the three-dimensional nursing management mode was determined according to the patient recovery.
The overall recovery effect in the experimental group was good, the respiratory function exercise effect was significant, and just one patient still had dyspnea after one week of nursing. There were 5 patients with chest tightness and chest pain and 7 patients with dyspnea in the control group. improving the patients' compliance with respiratory function exercises and to the nursing efficiency. It can greatly improve the nursing efficiency, relieve patients' post-surgical pain, and can promote the formation of a good doctor-patient relationship to a certain extent.This study aimed to investigate the clinical significance of multi-drug resistant organism (MDRO) screening and infection risk factor analysis in the intensive care unit (ICU).
A total of 210 patients treated in the ICU of our hospital were enrolled as the study subjects, and were divided into the MDRO group (n=100 cases) and the non-MDRO group (n=110) according to the presence or absence of MDRO infection after examination of the pharyngeal swabs. The pathogens of MDRO infection and drug resistance were analyzed. The single-factor as well as multifactor logistic regression analysis of MDRO infections were carried out and the 30-d mortality rate, hospitalization time and treatment costs were compared between the two groups.
A total of 158 MDRO strains were detected in 100 patients with MDRO infection, of which G-84 accounted for 53.16% and G+ 74 accounted for 46.84%. The resistance analysis revealed that G-MDRO was sensitive to imipenem and G+ MDRO was sensitive to vancomycin, and no vancomycin-resistant MDROs were found. The logistic regression model and multifactorial analysis showed that mechanical ventilation, arterial and venous intubation, implementation of fiberoptic bronchoscopy, concurrent chronic lung disease and chronic cardiovascular disease were independent risk factors for the development of MDRO infection (&lt;0.05). The length of hospital stay, cost of treatment, and 30-d mortality rate in the MDRO group were significantly higher than those in the non-MDRO group (&lt;0.05).
ICU mechanical ventilation, arterial and intravenous intubation, fiberoptic bronchoscopy, concurrent chronic lung disease and chronic cardiovascular disease are the independent risk factors for MDRO infection.
ICU mechanical ventilation, arterial and intravenous intubation, fiberoptic bronchoscopy, concurrent chronic lung disease and chronic cardiovascular disease are the independent risk factors for MDRO infection.